Aspartame
Of all of the low- and no-calorie sweeteners, aspartame has a sweetness that most closely replicates the taste of table sugar. Because aspartame is made up of two naturally occurring amino acids, which yield 4 calories per gram, aspartame is technically a caloric sweetener. However, because it is also about 200 times sweeter than sugar, 190 milligrams (~1 calorie) of aspartame has the same sweetening power as about 40 grams (160 calories) of sugar.
Consumer safety concerns regarding aspartame often stem from a misunderstanding of its metabolism, and animal studies that have been misinterpreted to infer that aspartame could increase hunger and food intake. However, the National Cancer Institute (NCI) and an independent international expert review panel have confirmed that aspartame does not cause cancer, seizures or other health problems, and an evidence-based research review by the Academy of Nutrition and Dietetics confirms aspartame does not increase in appetite or food intake. Aspartame is permitted for use in more than 100 countries worldwide. It is one of the most thoroughly studied food ingredients in the world. Aspartame is found in table top sweeteners like Equal®.
Articles
- Aspartame Safety: ADI, Metabolism, Estimated Intakes and Common Concerns
- Aspartame: Impact on Appetite, Food Intake, and Weight Management
- European Food Safety Authority Reaffirms Aspartame Safety
- No Relationship Between Low-Calorie Sweeteners and Cancer (CCC)
- Study Finds Aspartame, Stevia Sweeteners Do Not Increase Hunger Levels or Increase Desire to Eat More (CCC)
- The Rigorous Road to Food Ingredient Approval (IFIC)
What Experts Say
- Are Artificial Sweeteners Safe? A Look at the Evidence (Cleveland Clinic)
- Aspartame: From Metabolism and Safety to Impact on Appetite and Body Weight. An interview with Bernadene Magnuson, PhD
- Nonnutritive Sweeteners: Current Use and Health Perspectives. A Scientific Statement From the American Heart Association and the American Diabetes Association (AHA/ADA). Circulation. 2012 Jul 24;126(4):509-19. Epub 2012 Jul 9.
- Use of Nutritive and Non-nutritive Sweeteners. Position of the Academy of Nutrition and Dietetics. J Acad Nutr Diet. 2012;112:739-758.
- Academy of Nutrition and Dietetics Evidence Analysis Library on Non-Nutritive Sweeteners. A systematic review of the human research on low- and no-calorie sweeteners. (Subscription required)
- Artificial Sweeteners and Cancer Fact Sheet (NIH/NCI)
- Aspartame (Health Canada)
- Aspartame Opinions: American Dietetic Association evidence-based analysis puts questions to rest (aspartame.net)
- EFSA Statement on the scientific evaluation of two studies related to the safety of artificial sweeteners. European Food Safety Authority, 2011.
- FDA'S food ingredient approval process - Safety assurance based on scientific assessment. Rulis AM, Levitt JA. Regul Toxicol Pharmacol. 2009 Feb;53(1):20-31. Epub 2008 Nov 1.
- Managing Sweetness. Towards Constructive, Workable Solutions (EUFIC)
CPE Programs, Webinars & Podcasts
- Addressing Questions about Aspartame and Stevia Sweeteners with Bernadene Magnuson, PhD and Marianella Herrera, MD (Free CPE Program)
- Low-Calorie Sweeteners & Weight Management: Help or Hindrance? with Adam Drewnowski, PhD (Free CPE Program)
- Non-Nutritive Sweeteners: Separating Sense from Non-Science with Joe Schwarcz, PhD
- Children's Dietary Recommendations: When Urban Myths, Opinions, Parental Perceptions and Evidence Collide with Ronald E. Kleinman, MD (Free CPE Program)
- Understanding Americans' Approach to Weight Management: The Role of Low-Calorie Sweeteners with Adam Drewnowski, PhD and Robyn Flipse, MS, RD (Free CPE program)
- A Practical Guide to Risk Communications (Free CPE Program - IFIC)
- Demystifying FDA's Food Ingredient Approval Process (Free CPE Program - CCC)
- The Lowdown on Low-Calorie Sweeteners (Free CPE Program - IFIC)
- Translating Epidemiology into Sound Public Health Advice with Douglas Weed, MD, PhD (Free CPE Program)
- Effectively Communicating Food and Nutrition Science (Free CPE Program - IFIC)
- Helping Consumers Get the “Big Picture” - Promoting a Healthful, Balanced Eating Pattern (Free CPE Program - IFIC)
- Interpreting Science in a Social Media World (IFIC)
- Managing Sweetness. Towards Constructive, Workable Solutions (EUFIC)
- Watch an interview with Dr. Steven Blair on the benefits of staying active for aging adults [Source: International Council on Active Aging]
- Aspartame Facts and Fiction (IFIC)
- Benefits of staying active for aging adults (Dr. Steven Blair; International Council on Active Aging)
Printable Downloads
- Low-Calorie Sweeteners, Appetite and Weight Management (IFIC)
- Artificial Sweeteners and Cancer Fact Sheet (NIH/NCI)
- Everything You Need to Know About Aspartame (IFIC)
One of a series of International Food Information Council educational brochures on low- and no-calorie sweeteners.
- IFIC Review: Low-Calorie Sweeteners and Health (IFIC)
- Low Calorie Sweeteners: Role and Benefits (ISA)
- Science Policy Paper on Aspartame (GMA)
This Grocery Manufacturers Association review summarizes scientific research, regulatory history, consumption and uses in foods and beverages, with attention to the science that addresses misinformation commonly found on the internet.
- The Role of Low-Calorie Sweeteners in Weight Control (CCC)
A Calorie Control Council publication.
Related References
- Consumption of Diet Drinks in the United States, 2009‒2010. Fakhouri THI, Kit BK, Ogden CL. Centers for Disease Control NCHS Data Brief. Oct. 2012; 109.
- Low-Calorie Sweeteners and Weight Control. (Supplement) J Nutr. 2012; 142:1132S-1133S.
- Nonnutritive Sweeteners: Current Use and Health Perspectives. A Scientific Statement From the American Heart Association and the American Diabetes Association (AHA/ADA). Circulation. 2012 Jul 24;126(4):509-19. Epub 2012 Jul 9.
- Use of Nutritive and Non-nutritive Sweeteners. Position of the Academy of Nutrition and Dietetics. J Acad Nutr Diet. 2012;112:739-758.
- A review of the effectiveness of aspartame in helping with weight control. Ashwell, M, Gibson, S, de la Hunty, A. Nutr Bull. 2006;31(2):115-128.
- Academy of Nutrition and Dietetics Evidence Analysis Library Aspartame (2009)
- Academy of Nutrition and Dietetics Evidence Analysis Library on Non-Nutritive Sweeteners. A systematic review of the human research on low- and no-calorie sweeteners. (Subscription required)
- Aspartame: a safety evaluation etc. Magnuson BA, Burdock GA, Doull J, Kroes RM, Marsh GM, Pariza MW, Spencer PS, Waddell WJ, Walker R, Williams GM. Crit Rev Toxicol, 2007; 37:629-727.
- Does diet-beverage intake affect dietary consumption patterns? Results from the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial. Piernas C, et al. Am J Clin Nutr. 2013; Mar;97(3):604-11.
- Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Anton SD, Martin CK, Han H, Coulon S, Cefalu WT, Geiselman P, Williamson DA. Appetite. 2010;55(1):37-43.
- EFSA Report of the Meetings on Aspartame with National Experts (2010)
- EFSA Statement on the scientific evaluation of two studies related to the safety of artificial sweeteners. European Food Safety Authority, 2011.
- FDA'S food ingredient approval process - Safety assurance based on scientific assessment. Rulis AM, Levitt JA. Regul Toxicol Pharmacol. 2009 Feb;53(1):20-31. Epub 2008 Nov 1.
- Food Standards Agency (U.K.). Committee on Toxicity opinion on methanol safety. 04 April 2011.
- In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats. Ryan AK, et al. Toxicol. Sci. (2010) 114(1): 133-148.
- Intense sweeteners and energy density of foods: implications for weight control. Drewnowski A. Eur J Clin Nutr. 1999 Oct; 53(10):757-63.
- Intense sweeteners, energy intake and the control of body weight. Bellisle F and Drewnowski A. European Journal of Clinical Nutrition. 2007; 61: 691-700.
- Low-calorie Sweeteners and Other Sugar Substitutes: A Review of the Safety Issues. Kroger M, Meister K, Kava R. Comp Rev Food Sci Food Safety. 2006;5(2):35 - 47.
- Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Mattes R and Popkin B. American Journal of Clinical Nutrition. 2009; 89:1-14.
Mattes R and Popkin B. American Journal of Clinical Nutrition. 2009; 89:1-14.
- Reported use of reduced-sugar foods and beverages reflect high-quality diets. Sigman-Grant MJ and Hsieh G J Food Sci. 2005; 70:S42-46.
- The effect of aspartame as part of a multidisciplinary weight-control program on short- and long term control of body weight. Blackburn GL, Kanders BS, Lavin PT, Keller SD, and Whatley J. Am J Clinl Nutr. 1997; 65, 409-418.
- Use of artificial sweeteners and fat-modified foods in weight loss maintainers and always-normal weight individuals. Phelan S, Lang W, Jordan D, Wing RR. Int J Obes 2009;33(10):1183-90.
Related Websites
- FamilyDoctor.org (AAFP)
- European Food Safety Authority (EFSA)
- Academy of Nutrition and Dietetics (AND)
- American Beverage Association (ABA)
- American Diabetes Association (ADA)
- Asian Food Information Council (AFIC)
- Aspartame Information Center (CCC)
- Aspartame Resource Center
- Calorie Control Council (CCC)
- ChooseMyPlate.gov (USDA)
- European Food Information Council (EUFIC)
- Food Standards Australia New Zealand (FSANZ)
- Health Canada
- International Food Information Council (IFIC)
- International Life Science Institute (ILSI)
- International Sweeteners Association (ISA)
- The National Cancer Institute (NIH/NCI)
- Cleveland Clinic
Safety First
♦ Acceptable Daily Intake (ADI), Metabolism, Intake Estimates and Common Concerns
Weight Management
♦ Impact on Appetite and Food Intake


